“Intravenous Self-Administration of C1-INH Concentrate for Hereditary Angioedema: A Retrospective Report of Real-World Experience on 13 Patients”
Ralph Shapiro, MD
This paper was published by Dr. Ralph Shapiro in the The Journal of Angioedema, Vol 1, issue 2, 2013. This study was conducted to provide a retrospective view of treatment patterns, safety, and feasibility of C1 esterase inhibitor (C1-INH) self-administered at home under real-world conditions. The concept of home management of hereditary angioedema (HAE) has been gaining favor in recent years and is recommended in recent HAE consensus guidelines.
This study was a retrospective review of longitudinal data gathered in routine follow-up of 13 patients with HAE who were trained to administer IV C1-INH concentrate at home, either as on-demand for acute attacks or as ongoing prophylaxis therapy. Training in the self-administration of C1-INH concentrate is provided by highly trained clinic staff to the patient and/or a parent, spouse, or caregiver.
This trial concluded that Self-administration of C1-INH as on-demand therapy or as a prophylaxis is a feasible strategy that can be used successfully to manage HAE.
Congratulations to Ralph Shapiro, MD on the publication of your study paper!!!